Imputation by random draws from a manually defined distribution

This function imputes missing values in a proteomics dataset by random draws from a manually defined distribution.

Usage

manual_impute(se, scale = 0.3, shift = 1.8)

Arguments

se

SummarizedExperiment, Proteomics data (output from make_se() or make_se_parse()). It is adviced to first remove proteins with too many missing values using filter_missval() and normalize the data using normalize_vsn().

scale

Numeric(1), Sets the width of the distribution relative to the standard deviation of the original distribution.

shift

Numeric(1), Sets the left-shift of the distribution (in standard deviations) from the median of the original distribution.

Value

A SummarizedExperiment object with imputed values